This report presents Kenya’s Reproductive Maternal Neonatal Child and Adolescent Health (RMNCAH) Investment Framework for Kenya to realize the Vision 2030, the Constitution of 2010 and the Health Sector Strategic and Investment Plan 2014-18 and Sustainable Development Goals (SDGs). This investment framework presents a prioritized set of smart interventions that could be scaled up during the next five years to rapidly improve the health outcomes of Kenyan women, children and adolescents. It presents a costed investment framework that lays out Kenya’s RMNCAH vision, defining the guiding principles and elaborating on the progress to date in attaining RMNCAH results as well as lessons learned, at global and country level, to inform transformational strategies for Kenya. It also explains the benefits of investing in RMNCAH and highlights the returns on investment and possible impacts.