This paper seeks to outline best practices in MAYE (Meaningful Adolescent and Youth Engagement) from existing literature and other global and national health initiatives; highlight examples from several GFF countries to better understand existing challenges and opportunities in MAYE; and make recommendations for enhancing MAYE in the GFF moving forward, at both global and country levels. While this paper focuses on key structures, processes, and stakeholders that are part of the GFF, the lessons and recommendations are applicable across all aspects of the GFF partnership and framework, and for all stakeholders engaging in the GFF.